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In the field of synthetic biology, universities and research teams are the driving force behind “0-to-1” innovation. However, when lab-scale discoveries—born in test tubes and shake flasks—need to transition into scalable, compliant, and market-ready products, they often encounter a critical bottleneck: “no production facility, no regulatory system, and no scale-up experience.” Building dedicated manufacturing facilities requires massive capital investment; establishing compliant quality systems is time-consuming; and process scale-up remains fraught with technical uncertainty. These formidable barriers cause many promising innovations to stall at the stage of publications and patents.   Changzhou Timerein Biotech Co., Ltd. has pioneered a next-generation CDMO (Contract Development and Manufacturing Organization) platform model. We go beyond offering technical services and process development—we provide ready-to-use, compliant, and fully operational manufacturing infrastructure and industrialization systems. In essence, we serve as the “industrialization home ground” for academic and research teams transitioning from the lab to the market. Our Key Advantages: 1. Ready-to-Use Facilities & Equipment – Plug-and-Play Production ·GMP-compliant Class 10,000 cleanrooms, meeting stringent standards for pharmaceutical and medical device manufacturing ·Scalable fermentation platform (10L–1000L), supporting seamless progression from process development to commercial production ·Integrated downstream processing: purification, lyophilization, and formulation capabilities for end-to-end manufacturing ·Advanced analytical testing lab equipped with HPLC, mass spectrometry (MS), and more—ensuring consistent product quality and traceability 2. Established Compliance Framework – Accelerated Regulatory Pathways ·Fully implemented dual quality management systems: GMP + ISO 13485 ·Holds 13 Class II/III medical device registrations—proven regulatory experience ready for reuse Completed Drug Master File (DMF) registration for recombinant collagen raw materials, providing a solid foundation for new product submissions 3. Proven Scale-Up Capabilities – Industry-Leading Performance ·Achieved ≥20 g/L expression titer of recombinant collagen in 1000L bioreactors—a benchmark in the industry ·Stable annual production capacity: >500 kg of Type III collagen and >100 kg of Type XVII collagen ·Maintains a library of over 100 recombinant collagen gene constructs, enabling rapid customization and product development The future of synthetic biology belongs to those who can rapidly and reliably bring innovation to market. At Timerein, we embrace the CDMO platform model to become the most trusted industrialization partner for academic and research teams.You focus on frontier discovery. We ensure real-world impact.If you’re seeking a partner with facilities, compliance expertise, and scale-up experience to transform your lab breakthroughs into competitive, branded products—we invite you to bring your technology vision to our industrialization ecosystem.From 1 to 100, we offer more than services—we provide the complete soil for your innovation to grow.

From May 15th to 22nd, 2025, Timerein Biotechnology Co., Ltd. passed the on-site system audit of the European Medical Device Regulation (MDR) with high scores. The evaluation team composed of senior audit experts from the EU notified body, after a rigorous 4-day review, confirmed that the company's quality management system meets the requirements of MDR regulations, and the systematic quality control has been internationally recognized, laying a solid foundation for the company's products to obtain CE certification.   Industry marvel: A new and emerging enterprise established only two and a half years ago passed the review with zero major non conformities and high scores! Technological accumulation and innovation strength break the international certification cycle record, redefining the "hardcore speed" of domestic medical beauty!Beauty Needle Microneedle Hydrafacial Machine  

Dear Beauty Industry Colleagues and Esteemed Beauty Enthusiasts, Today, we announce with immense excitement and pride that the ‌Timerein Hydrafacial Machine has officially passed the rigorous review by the ‌Jiangsu Provincial Medical Products Administration‌ and obtained its ‌Medical Device Registration Certificate‌ (Registration Certificate No.: Su Xie Zhun 20252140737). This official certification not only marks Timerein’s ‌dual breakthroughs in technological innovation and medical compliance‌ but also signifies that China’s intelligent skincare devices have officially entered a ‌new era of safer, more precise, and intelligent‌ beauty technology! The medical device registration certificate is not only an endorsement of product safety and effectiveness, but also a golden signboard of the brand's commitment to user health. Timerein has always regarded "medical compliance" as the core principle of research and development. After thousands of tests and rigorous review processes, it has finally been recognized by the drug regulatory authority. This certificate is not only a recognition of our research team's years of deep cultivation, but also a solemn guarantee for the safety and beauty of every user!  Thread Lift As China's first aqua injection device equipped with a voice interaction system, ‌Timerein Hydrafacial Machine redefines skincare experiences through dual-core innovation in "technology + medical compliance‌:‌Microneedle ‌Voice-Activated Safety‌ Industry-first voice command operation enables zero-contact control, eliminating cross-contamination risks from traditional button interfaces and elevating sterile protocols.   ‌Micro-Precision Personalization‌ 0.01ml fluid accuracy with intelligent multi-dimensional parameter adjustment (suction intensity, dosage, speed) to address personalized needs: sensitive skin, anti-aging, hydration, collagen supplementation，and beyond.   ‌Dual-Mode Versatility‌ Seamless switching between Full-Auto Mode (ensures standardized treatment efficacy) and Expert Manual Mode (allows seasoned professionals customized precision).   At this moment, we are grateful for the professional guidance of relevant regulatory authorities, the strong support of our partners, and the trust of countless users. Timerein will take this certification as a starting point, continue to deepen its cultivation in the field of medical beauty technology, safeguard safety with compliance, and empower beauty with innovation!     

On the afternoon of November 27, 2024, Wang Fei, Deputy District Chief of Wujin District, Changzhou City, led a team to visit Changzhou Timerein Biotechnology Co., Ltd. for research and visit. The purpose of this visit is to gain a deeper understanding of Timerein Biology's layout in the field of synthetic biology, as well as the progress of the construction of the recombinant collagen pilot platform. The two sides had in-depth exchanges and the atmosphere of the talks was harmonious. Accompanied by the Chairman and senior management of Timerein Biotechnology, Vice District Chief Wang Fei and his delegation first visited the company's research and development center and production workshop. Through on-site investigation, the research team has gained a clear understanding of the technological innovation and production capacity of Timerein Biology in synthetic biology. Subsequently, both parties had a detailed discussion and exchange in the conference room. At the symposium, the technical team of Timerein Biology provided a detailed introduction to the company's strategic layout in the field of synthetic biology, including the latest research and development achievements and future development plans. In response to the progress of the recombinant collagen pilot platform, Timerein Biology demonstrated its advanced equipment and technological advantages. The platform not only improves production efficiency but also ensures consistency and stability in product quality. In addition, Timerein Biotechnology also shared the market performance of existing recombinant collagen products. With excellent product quality and good user reputation, the company's products have gained widespread recognition in the market. Especially in the field of light medical beauty consumables, Timerein Biotechnology has become one of the enterprises with the most complete compliance certificates in the country, with an annual production capacity reaching the leading level in the industry. Vice District Mayor Wang Fei highly praised the investment and achievements of Timerein Biology in this field, and stated that the government will continue to support the innovative development of enterprises.  

Recently, Changzhou Timerein Biotechnology Co., Ltd. (hereinafter referred to as "Timerein Biotechnology") located in the National Medical Device Incubation Park announced that its independently developed recombinant XVII type collagen protein trial has been successful. This achievement marks an important step forward for the company in the research and production of synthetic biology.   Since its establishment, Timerein Biotechnology has been committed to the research and development of synthetic biology, especially in the field of recombinant collagen, and has made significant progress. The company has successfully developed and applied various recombinant collagen proteins, including type I, III, and XVII collagen proteins, which have shown excellent performance in fields such as medical beauty, wound repair, and tissue engineering. The successful trial production of recombinant type XVII collagen not only further enriches the company's product line, but also provides a more efficient and safe selection of new biomaterials for domestic and international markets.     According to relevant information, recombinant type XVII collagen is an important extracellular matrix protein that is widely present in the skin, bones, and other connective tissues of the human body. It plays a critical role in maintaining tissue structure integrity and promoting wound healing. Compared with traditional animal derived collagen, recombinant type XVII collagen has higher biocompatibility and lower immunogenicity, making it more widely applicable in fields such as medical beauty and wound repair.     Timerein Biotechnology has successfully achieved small-scale production of recombinant XVII type collagen through advanced synthetic biology technology. During this process, the research team overcame many technical difficulties, optimized the expression system, significantly improved the purity and activity of the product, and ensured the functionality and safety of the new collagen protein.     The project leader of the company stated that the successful small-scale trial is just a good start. Timerein Biotechnology will continue to promote the construction of the pilot production line and plan to achieve 1000L pilot production of recombinant XVII collagen protein in the first half of 2025. At the same time, the company is actively exploring the potential applications of this new collagen protein in other medical and health fields, striving to bring more innovative products to the market.   With the increasing demand for high-quality biopharmaceutical products from users, Timerein Biotechnology will continue to adhere to the innovation driven development strategy, deepen industry university research cooperation, and strive to transform more high-quality scientific research achievements into actual productivity, making greater contributions to the cause of human health.

On August 23, 2024, Changzhou Timerein Biotechnology Co., Ltd. successfully obtained a Class II medical device registration certificate issued by the Jiangsu Provincial Drug Administration for the Recombinant collagen sterile patch. Recombinant collagen sterile patch is composed of recombinant collagen, glycerol, carbomer, triethanolamine, phenoxyethanol, purified water, and non-woven fabric, which are encapsulated in an aluminum foil bag. This product is provided in a sterile state, sterilized by irradiation, and disposable. The product acts as a physical barrier by forming a protective layer on the surface of the wound. Used for non chronic wounds (such as superficial wounds, mechanical wounds, small wounds, first-degree or shallow second degree burn wounds, wounds after laser/photon/fruit acid skin exchange/micro plastic surgery) and surrounding skin care. Compared with ordinary facial mask, recombinant collagen aseptic application has higher requirements for the production environment. It is produced in a clean environment, and its ingredients are safer. It does not add hormones, chemical preservatives, artificial essence, fluorescent agents and other ingredients, so it is more suitable for sensitive muscles and skin with damaged skin barriers. It also plays an auxiliary role in the treatment of a variety of skin problems, and can also be used for postoperative care of photoelectric and other projects. The approval of the Class II medical device registration certificate for recombinant collagen sterile patch by Timereini Biotechnology is not only the result of the company's years of innovation driven efforts, but also a solid step taken by the company in response to the broad market demand. In the future, the company will continue to increase research and development investment, continuously optimize product performance, promote innovation and application of more products, constantly explore new technologies and products, adhere to the mission of "not only beauty,but safety", and provide safer and more effective products for the field of biomedical consumables.

From May 10th to 12th, 2024, the three-day Mevos International Medical Beauty Conference was successfully concluded at the Hangzhou International Expo Center! This grand event has not only become the focus of the medical beauty industry with its grand scale and extensive influence, but also an open platform that gathers experts from multiple fields, showcases cutting-edge technologies, and promotes in-depth exchanges.   As a new force in the domestic medical beauty industry, Timerein Biotechnology Co. , Ltd. was invited to participate in this grand event.  Adhering to the corporate mission of "not only beauty, but safety", Timerein appeared at the exhibition with its brand product, showcasing its latest achievements and innovative strength in the field of medical aesthetics. The attendees showed strong interest in the products exhibited on display and actively communicated with the staff. Timerein has received enthusiastic feedback and support from experts and visitors from all walks of life, and has accumulated numerous cooperation opportunities and friendship, which will lay a solid foundation for the future development of the company. At the same time, it has also strengthened our determination to improve product quality and promote industry innovation.   On the platform of the Mevos Conference, Timerein Biotechnology Co. , Ltd. fully demonstrated its strong comprehensive strength and met more high-quality partners. In the future, we will continue to explore industry boundaries with scientific concepts and technologies, deeply cultivate the market, and strive to create a first-class innovation highland in the synthetic biology industry. We will develop and design more scientific and safer light medical aesthetic products, opening a new chapter in technological aesthetics!      

On April 18th, the Standing Committee of the District  Political Consultative Conference held a research symposium on the consultation topic of "preemptively laying out the future industry track and promoting high-quality development of the synthetic biology industry". Zheng Zhengping, Secretary and Chairman of the Party Group of the District Political Consultative Conference, Zhu Huifeng, Deputy District Mayor, and Yi Jianliang, Member of the Party Group and Secretary General of the District Political Consultative Conference, participated in the event. The research team visited Taimeirui Biotechnology Co.,Ltd. on site to gain a detailed understanding of the company's development status. They had in-depth exchanges with the company's leaders on cutting-edge synthetic biology technologies, industry development trends, and listened to opinions and suggestions. Taimeirui has actively expanded its presence in the field of synthetic biology by establishing collaborations with universities and institutions, as well as investing in recombinant human collagen implant projects, thereby providing robust support for the advancement of the synthetic biology industry.   Taimeirui always adheres to the business philosophy of "precision, refinement, and excellence". We are committed to providing a one-stop solution for high-end medical device products in the light medical beauty industry with advanced minimally invasive surgical equipment products and high-quality customer service. The company is equipped with 1000 square meters of 100,000-class purification plant and 500 square meters of 10,000-class purification workshop, which meets the production conditions of Class III medical devices required by the National Medical Products Administration, and complies with ISO13485 quality management system and ensures its effective implementation. It has 500 square meters of physical/chemical laboratory, class 10,000 biological laboratory (positive control, microbial limit, sterile laboratory), and has more than 100 pieces of equipped experimental equipment and instruments (gas chromatograph/quadratic tester/tensile testing/imaging instrument/constant temperature aging box, etc.).   After this discussion and exchange, Zheng Zhengping, Secretary of the Party Group and Chairman of the District Political Consultative Conference, fully affirmed the development achievements of our company's synthetic biology industry.

Changzhou Timerein Biotechnology Co., Ltd. is located in Changzhou National Pharmaceutical Industry Incubation Park. It is the 17th batch of Changzhou City's "Dragon City Talents" key projects and Jiangsu Province's mass entrepreneurship and innovation plan project. It is a high-tech company dedicated to the production and sales of the entire industry chain of consumables, products, and equipment, and the development of one-stop solutions. The company has a 1,000-square-meter 100,000-level purification workshop, a 500-square-meter 100,000-level purification workshop, a two-level reverse osmosis purified water system, a constant temperature and humidity air conditioning system, and a clean compressed air system; a 350-square-meter physical and chemical laboratory, and a 10,000-level biological experiment. Laboratory (positive control, biological limits, sterile laboratory); more than 100 sets of supporting experimental equipment (gas chromatography/integrated/camera/tensile test/fatigue test/constant temperature aging box/autoclave/cryogenic refrigerator, etc. ), complies with the standards of the State Food and Drug Administration, meets the highest standards required by the State Food and Drug Administration for the production of all Class III medical devices, complies with the ISO 13485 quality management system and ensures effective implementation.

On the morning of February 22, Changzhou West Taihu Science and Technology Industrial Park held a development conference on "Cultivating New Productivity and Building the Most Beautiful Lake Bay City" to implement the mobilization meeting for the city's trillion-dollar city to start again and the district's joint demonstration to demonstrate its first responsibility - - The requirements of the "Trillion-Billion City Start Again" development conference mobilized the entire park to strengthen confidence, seize opportunities, and jointly write a new chapter in the construction of Huwan New City. Qiao Junjie, member of the Standing Committee of the Municipal Party Committee and Secretary of the District Party Committee, attended the meeting and delivered a speech. District leaders Zhao Gang, Sun Yifeng, Xu Jun, Jiang Hongying, and all members of the leadership team of the West Taihu Party Working Committee and Management Committee attended the meeting. At the West Taihu Science and Technology Industrial Park Development Conference, Changzhou Taimeirui Biotechnology Co., Ltd. was awarded the "Excellent Science and Technology Enterprise" commendation for its outstanding achievements and outstanding performance in its work in 2023.Microneedle Go on stage to receive the award and take a group photo.Roller Needle Taimeirui Biotechnology Co., Ltd. is located in the national medical device incubator park in Changzhou City. It is a key "Dragon City Talents" project introduced by Changzhou City and a preferred mass entrepreneurship and innovation project in Jiangsu Province. The company is mainly engaged in the rapid development of high-tech companies integrating the research and development, production and sales of light medical beauty track consumables, functional recycled materials and optoelectronic equipment products.Blunt-End Needle Taimeirui adheres to the corporate mission of "more than beauty, but also safety", is driven by biotechnology, based on precision manufacturing, adheres to the concept of long-term strategy and win-win cooperation, and is committed to becoming a leader in the light medical beauty industry.

What is a sharp needle: Sharp needles have a beveled tip, which is sharp, fine and hard enough to directly pierce the epidermis of the skin and enter into the subcutaneous area, and the exit of the agent is designed at the tip of the needle, which is usually used for infusion, injection and other injection operations. Advantages of sharp needles: 1. a variety of injection materials in the original that is a sharp needle; no need to replace the needle; ready to use; easy to operate; low cost 2. the injection technique is flexible and versatile; a variety of techniques can be used; can be flexible in multiple planes, multiple injection points for free switching and fine-tuning; 3. Sharp needle is finer, and if used properly, the level is accurate, resulting in less tissue damage, and less pain, relatively safe 4. suitable for injections of face slimming, shoulder slimming, leg slimming, wrinkle removal, lipolysis, hydration, like hyaluronic acid as well 5. Recommended filler parts: silkworms, lips, chin, nose base and so on.

On December 26th, Changzhou Timerein Biotechnology Co., Ltd. held the signing ceremony of "Synthetic Biology Joint Innovation Laboratory, Medical Beauty Industrial Design and Clinical Experiment Base", the new product launching ceremony and the first anniversary celebration in West Taihu. Provincial Drug Administration Changzhou inspection branch director, the provincial Drug Administration review and verification of Changzhou Branch Center Director Liu Yuzhi, District Standing Committee, West Taihu Party Secretary Xu Jun, park leaders Hu Yanhong, Shen Liren attended the signing activities. Speech by Leader Mr. Liu Yuzhi Changzhou Inspection Branch will give full play to the functions of Changzhou Biomedical Industry High Quality Development Task Force Office, implement the general requirements of the Central Economic Work Conference "seeking progress while stabilizing, promoting stabilization by progressing, and establishing before breaking", and deal with the relationship between "seeking" and "doing" relationship. Further focus on serving the development of local pharmaceutical industry, give full play to the innate advantages of being close to the park and enterprises, and take the initiative to integrate into the layout of Changzhou biomedical industry, park development, as well as the platform construction. On the basis of firmly guarding the bottom line of drug safety, insist on asking for the needs of enterprises and serving them, and help the high-quality development of Changzhou's biomedical industry to a new level. Speech by Leader Mr. Xu Jun Xu Jun hopes that Timerein will take today's signing as an opportunity to further strengthen the basic research and technology transformation, so that more scientific research results will come out of the laboratory, enter thousands of households, and go to all corners of the world. The park will further optimize the industrial ecology, introduce more and better elemental resources, constantly innovate and improve policies and measures to create an optimal business environment, and serve innovation and entrepreneurship with the greatest sincerity and strongest initiatives. Speech by General Manager Mr. Li Changchun Mr. Li said that synthetic biology is known as the "third biotechnology revolution", many regions are ready to go, and we in Changzhou are seizing the first opportunity to plan, cultivate the future industry, and create a synthetic biology industry innovation highland; Timerein Biotechnology, as a member of West Taihu Biological Island, is also actively seeking for new growth pointers for the future development. We have become one of the most fully licensed companies in the field of light medical and aesthetic consumables in China, and also a manufacturer with the highest degree of automation in the production of light medical and aesthetic consumables in China, which is now equipped with five sets of fully automated production lines. Through half a year's efforts, the company's brand has a certain degree of visibility in the industry, and has been with the medical aesthetic industry, high-end chain organizations such as Mei Lai / Lang Zi/ Su Wang Media / Zhi Mei, more than 2,000 organizations across the country to cooperate, and strive to cooperate with more than 10,000 organizations next year. The signing of this strategic cooperation also signifies that Timerein has stepped into a new stage of development. Signing Ceremony As a preferred project of Double Innovation in Jiangsu Province and a key project of "Longcheng Talents" introduced by Changzhou City, Timerein settled in West Taihu at the end of 2022 and entered the light medical aesthetic track, with an annual output of 8 million nine needles, 30 million blunt-end injection needles and sharp needles. It has obtained two Class II medical device registration certificates and four Class III medical device registration certificates. This year, Timerein actively expand the field of synthetic biology, and cooperate with universities and institutes, investing 50 million yuan to build a recombinant human collagen implant project, providing strong support for the development of synthetic biology industry in the park. Introducing the whole-process quality control system of Timerein, sharing the design and development process of products, and reporting the progress of the research and development of synthetic biology-related products. Management Representative Hu Yanling R&D Representative Zhang Hao Deputy General Manager Zhang Xiaodong First Anniversary Celebration Mr. Li Changchun, General Manager of Changzhou Timerein Biotechnology Co., Ltd. firstly made a one-year anniversary report. Mr. Li shared the report sheet of Timerein's achievements in the past year through the data. At the same time, he also shared the shortcomings and improvement plans. At the meeting, Mr. Li also proposed that Timerein will adhere to the corporate mission of "not only beauty but safety", driven by biotechnology, based on precision manufacturing, with a long-term strategy and win-win cooperation, and strive to become a leader in the light medical aesthetic industry.

Timerein Biotechnology Co., Ltd. is located in Changzhou National Medical Device Incubation Park, which is the key project of "Longcheng Talents" introduced by Changzhou City, and the preferred project of Double Innovation in Jiangsu Province. The company is a high-tech company mainly engaged in the research and development, production and sales of light medical aesthetic track consumables, functional regenerative materials and optoelectronic equipment. Adhering to the corporate mission of "not only beauty but safety", driven by biotechnology, based on precision manufacturing, and adhering to the concept of long-term strategy and win-win cooperation, Timerein is committed to becoming a leader in the light medical aesthetic industry. Changzhou West Taihu International Innovation Center of Pharmaceutical Science and Technology is a national medical device innovation park and a medical industrial park jointly built by Jiangsu Provincial Drug Administration and Changzhou Municipal People's Government. It has been awarded the titles of "Changzhou National Medical Device International Innovation Park" by the Ministry of Science and Technology, "National Demonstration Base for Upgrading and Transformation of Foreign Trade in Medical Devices" by the Ministry of Commerce, and "Changzhou International Medical Tourism Pioneer Zone" by Jiangsu Provincial Government, etc. With a sales revenue of more than 5 billion RMB achieved by enterprises of the park's medical healthcare industry in 2019, the healthcare industry in the park has already become the healthcare industry cluster with most visibility and potential in the Yangtze River Delta. Products on display in our company Anti-aging equipment category: hydrafacial machine (Class II) Functional products: sodium hyaluronate (Class II) and recombinant type III collagen face mask (Class II) Injection consumables: sterile injection needle with 9 pins (Class III), blunt-end injection needle (Class III), ultra-fine sharp needle (34G) (Class III), roller needle (Class II), PRP platelet-rich plasma (Class III) The opening of Timerein exhibition counter not only provides a platform for Timerein Biotechnology to focus on showing its corporate culture, corporate image and highlighting its corporate value, but also provides a good environment for guests, leaders and cooperative units to understand Timerein Biotechnology and get to know Timerein Biotechnology, which makes a strong support for the company's culture.

On 21st November, 2023 Changzhou-Wujin Talent Week, "To Develop in Wujin,No End to Progress" , was opened. With the theme of "'Four Chains' Integration and Shared 'Wujin' Future", the Talent Week carries out a series of activities centred on the integration of production and talent, pioneering navigation, rural revitalization and talent ecology, aiming to build a new platform for gathering talents, boosting industries and empowering development. Shen Xuechu, academician of Chinese Academy of Sciences, Ben De, Zhang Quanxing, academician of Chinese Academy of Engineering, Wei Dongqing, academician of UK Royal Institute of Chemistry, Chen Xiang, Qiao Junjie, Hu Bo, Zhu Yan, Zhu Huifeng, Zhao Shaohua, city and district leaders attended the event. Our company was invited to participate in the Wujin Talent Week, "To Develop in Wujin,No End to Progress" and Mr. Li Changchun, General Manager of Timerein Biotechnology, participated in the signing of the four-chain integration project of the big health industry chain project, and reached a strategic and friendly cooperation between "Collagen Biological Products Clinical Trial Base Project" and West-Taihu Hospital. After the meeting, the leaders of Wujin District, professors of Nanjing University, Professor Zhang Quanxing and Dr. Wei Dongqing and their group visited our company on biosynthesis engineering. The two sides made in-depth exchanges on the enterprise planning and strategic layout of our company. The visit not only enhanced the understanding between the two sides, but also laid a solid foundation for deepening cooperation in the future.

" Warmly welcome the leadership to visit and guide." With the corporate mission of "not only beauty but safety", driven by biotechnology, based on precision manufacturing, and adhering to the concept of long-term strategy and win-win cooperation, Timerein is committed to becoming a leader in the light medical aesthetic industry. 01 The company is equipped with 1000 square meters of 100,000-class purification plant and 500 square meters of 10,000-class purification workshop, which meets the production conditions of Class III medical devices required by the National Medical Products Administration, and complies with ISO13485 quality management system and ensures its effective implementation. 02 Timerein has always adhered to the business philosophy of "Precision, Exquisiteness and Advancement". We are committed to providing one-stop solutions for the light medical and aesthetic industry with advanced minimally invasive surgical equipment products and high quality customer service. 03 The company has 500 square meters of physical/chemical laboratory, class 10,000 biological laboratory (positive control, microbial limit, sterile laboratory), and has more than 100 pieces of equipped experimental equipment and instruments (gas chromatograph/quadratic tester/tensile testing/imaging instrument/constant temperature aging box, etc.). 04 After this discussion and exchange, the leaders of both sides earnestly hope that further cooperation can be made and regular contact can be maintained, and the development strategies of both sides are very suitable and the future can be expected!

With the improvement of living standards and the rise of the demand for self-pleasing, medical aesthetics has gradually become a way for everyone to become beautiful on a daily basis. People are becoming more and more aware of skincare, and some beauty seekers no longer seem to be satisfied with basic skin care, preferring to choose non-surgical light medical aesthetic programs. As we all know, the nutrients of the basic skincare operations such as make-up toner and lotion and masks that we use in our daily life usually stay on the surface, and it is difficult to enter the deeper layers of the skin; whereas, the hydrafacial program can deliver nutrients through the epidermis directly to the dermis layer, alleviating skin problems from the deeper layers; as an entry-level medical aesthetic program, it is not only simple to operate, with a short recovery period, but also time-saving and highly efficient, and therefore it has become a choice of many aesthetics lovers. Hydrafacial program belongs to the mesotherapy. Injection with the help of devices and needles, the requirements of the hydrafacial machine is also very strict. For consumers, there are a lot of hydrafacial machines on the market, and it is not easy to screen whether the machine is compliant and which machine to choose. Based on the huge market demand, the subcutaneous electronic syringe booster device was born. Our company has taken the certificate on October 30, 2023 - 20232141537(Registration Admission of Medical Device in Jiangsu Province), welcome to consult with us.

Riding on the east wind of the "two lakes" innovation zone, accelerate the construction of "government, industry, academia, research and gold taking" innovation and entrepreneurship community, the morning of October 30, West Tai Lake Synthetic Biology Innovation Industrial Park was inaugurated, to seize the forefront of the synthetic biology industry. Hu Zhibin, President of Nanjing Medical University, and Chen Jinhu, Secretary of Municipal Party Committee, attended the inauguration ceremony. Synthetic biology is a new round of industrial updating "must contend field". The construction of West Lake Synthetic Biology Industrial Innovation Park is a key step for Changzhou to accelerate the pace and seize the high ground on the synthetic biology track, as well as a firm step for cultivating the "two lakes" innovation zone and planting new productivity, which will provide guarantee for accelerating the whole process of industrial innovation ecological chain of "basic research + technology research + industrialization of achievements + science and technology + finance + talent support". During the event, the cell research project, Smart Peptide Biocreative Biomaterials Project, Synthetic Biomaterials Manufacturing Base Project, Collagen Bioproducts Project (Changzhou Timerein Biotechnology Co., Ltd.), Cellular Laboratory System and Preparation Manufacturing System Project, New Energy Battery Materials Project, and Probiotic Bacteria Polysaccharide Industrialization Project signed a contract to settle in the city. West Tai Lake Synthetic Biology Industry Angel Investment Fund was established. Deep Venture Capital, Songhe Capital, Jinyumaowu, Wangxi Capital and Weilai Capital, together with Wujin Guojing Group and Weich Group, launched the West Tai Lake Synthetic Biology Industry Investment Alliance, which empowers the development of the industry with capital, and opens up the whole chain of synthetic biology frontier technology research, scientific and technological achievement transformation, and industrial innovation and development.

Importance of Collagen Collagen is the most abundant protein in the human body, about 70% of the human body is composed of collagen, which is most abundant in tissues such as skin, bones, cartilage, blood vessels and tendons. Collagen can be said to be the umbrella for the health of our skin and a substance for the internal health of our body. If collagen loss is serious, it will lead to the aging of the internal tissues of the human body, which is the reason why some people find significant changes in the internal and external parts of their body when they grow old. In addition, external factors such as stress in daily life, bad habits, and ultraviolet radiation can accelerate collagen degradation and aging. These factors lead to problems such as fine lines, sagging, dryness and wrinkles, making the skin look less youthful and healthy. Role of Collagen Wound Dressing Recombinant type III humanized collagen wound dressing has a wide range of applications in the field of cosmetology. Its role is mainly reflected in the following aspects. First, collagen dressing can provide sufficient collagen for the skin. Collagen is an important part of the skin, filling the skin fine lines, making the skin become more full and smooth. By applying collagen, we are able to deliver this important protein directly to the skin, providing the nutrients and support it needs. Second, collagen dressing can improve skin texture and enhance skin elasticity and firmness. As we age and with the influence of the external environment, the skin loses collagen gradually, leading to skin laxity. By applying collagen, we are able to replenish the collagen needed by the skin, helping to restore the skin's elasticity and firmness. At the same time, collagen is also able to improve the elasticity of the skin, making it more resilient and tension. Third, collagen dressing can also promote skin repair and regeneration. Skin damage by various factors, such as ultraviolet radiation, free radical damage, etc., will lead to the destruction of cell structure. By applying collagen, we are able to provide the skin with the nutrients and support it needs, promote cell repair and regeneration, and revitalize the skin. Overall, Recombinant Type III Humanized Collagen Wound Dressing fills in the fine lines of the skin, improves skin texture, enhances skin elasticity, and promotes skin repair and regeneration by providing sufficient collagen. It is a safe and effective skincare method for people to solve the problems of skin aging and texture. Therefore, it is widely used and praised in the field of cosmetology.

Sodium hyaluronate is injected into the dermis close to the epidermis through injection needles. This is commonly known as the hydration injectcion needle, and its professional name is mesoderm therapy. The working principle of the hydration inection needle is very simple, which is to use medical means to inject nutrients and moisture directly into the deep layer of the skin through the needle to treat skin spots, dull skin tone, dark circles, acnes, acne marks, fine lines, sensitive skin and other problems. Our daily skincare products also contain various nutrients, but they can only be applied to the skin epidermis. Therefore, the hydration injection needle can be understood as an advanced version of skincare products. From the epidermis "deep" to the dermis, the supply of various nutrients is more powerful and the effect is better. If injected into the dermis, it can be the basic hydration series. The main components of basic hydration are water and hyaluronic acid (no crosslinked or low crosslinked hyaluronic acid). It has a special water retention effect and is the best moisturizing substance found in nature (2% pure hyaluronic acid aqueous solution can maintain 98% moisture); so it can not only maintain skin elasticity, but also lock large Measure water molecules, and the skin becomes delicate, smooth, moisturizing and fair due to sufficient moisture. Our company has newly launched basic hydration products, and has obstained the second-class registration certificate of the Provincial Food and Drug Asministration.

As a new company after the existence and separation of Timerein (Changzhou) Medical Devices Co., Ltd., Changzhou Timerein Biotechnology Co., Ltd. needs to divide the original company's assets into Class III medical device products (disposable sterile injection needle) and Class II medical device products (disposable sterile roller needle) The rights are transferred to the new company. This matter is complicated and time-consuming, involving multi-level and multi-departments such as national bureaus, provincial bureaus and sub-bureaus, and sub-centers. The key is that there is no experience to learn from the relevant changes to the registration certificate after the existence of separation. After the relevant leaders of the Provincial Bureau, Changzhou Inspection Branch and Sub-center learned about this, they immediately arranged someone to provide us with policy advice, took the trouble to carry out guidance, and actively helped coordinate various resources, and even gave up weekend rest days to the enterprise for on-site physical examination, and finally helped our enterprise in just two months. The transfer of the two product registration certificates of the new company, the application of the production license and the addition of the new production address of West Taihu Lake have been completed. After the completion of this matter, the change of the production address and registrant's residence on the two product registration certificates was completed in just one week. The existence and division of changing the Class II and Class III registration certificate, applying for and changing the production license and the new production address is the first high-frequency change in Jiangsu Province, and it is rare in the country. In the whole process of applying for change, the Administrative Examination and Approval Office of the Provincial Food and Drug Administration, the Medical Device Production Supervision Office, the Evaluation Center, the Audit and Inspection Center, and the Changzhou Branch and Sub-center are urgent for enterprises. They actively provide us with policy consultation and business guidance, issue certificates in a timely manner, speed up the review and approval progress, and be faster and more efficient. Helping enterprises to realize the timely conversion of production after existence and division has minimized the impact of our company on the production and sales of enterprises in the stage of license change. Let enterprises deeply feel the "supervision and unlimited service"!